CD306 LAIR-2 (leukocyte associated immunoglobulin-like receptor 2)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Putative Secreted Protein
T Cell
Monocyte
16 / 16

Expression
CD306 is expressed on monocytes, T cells and putative secreted proteins.

Structure
MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family.

CD306 is a single-pass type-1 152 aa glycoprotein.  It contains an extracellular domain which contains an Ig-like 2-type domain and a potential N-glycosylation site but it lacks a transmembrane domain and cytoplasmic domains.  CD306 was first identified by its similarity to CD305 (LAIR-1) which show 84% homology.  CD306 is an inhibitory receptor present on mononuclear leukocytes. 

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.  The isoforms lack the transmembrane domain and cytoplasmic domain suggesting that they are soluble or attached to the membrane indirectly.

POST-TRANSLATIONAL MODIFICATION

CD306 has a potential N-glycosylation site.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD306

CD306 is associated with Ep-CAM.

Function
The function of CD306 is unknown but it has been suggested that it is a secreted protein form of  CD305 and may help modulate mucosal tolerance.  CD306 is thought to inhibit cellular activation and inflammation. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD306 IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD306: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD306: No information.

ADDITIONAL INSIGHTS

For further information see Meyaards, L. et al (1997) Immunity 7: 283-290.




Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 3904Q61SS4
Antibodies

Revised June 25, 2008


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