|CD314|| KLRK1 (killer cell lectin-like receptor subfamily K member 1), NKG2D|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 2 glycoprotein
|42 / 42|
|CD314 is expressed on human NK cells, CD8+ T cells, a minor subset CD4+ T cells and , on some myeloid cells. Expression is essentially all CD56+CD3-NK cells from freshly isolated PBMC and also detected in CD8-αβ T cells. Mice express CD314 on NK cells, γ/δ and a subset of NK1.1 T cells as well as on activated macrophages.|
MOLECULAR FAMILY NAME: Belongs to the C-type lectin family.
|LIGANDS AND MOLECULE ASSOCIATED WITH CD314|
CD314 binds strongly to at least 6 ligands in the human, all of which are related to MHC class I. They are MICA, MICB, H60, ULBPs (1-3) and RAE-1. MICA and MICB have been identified as ligands for CD314. Binding of ligand to receptor activates NK cells and co-stimulates T cells. Engagement activates cytolysis and cytokine production. Mice have orthologs of the ULBP genes but lack MIC genes.
|CD314 exists as a homodimer and interacts together with DAP10 which is required for cell surface expression. The receptor for MICA, MICB and MLBP1-3 plays a role for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T cells and is involved in the immune surveillance exerted by T and B lymphocytes. This protein may also play a role in regulating lymphocyte adhesion. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contain several C-type lectin genes, preferentially expressed on NK cells. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD314 IN INTACT ANIMAL
CD314 may play a role on integrin dependent morphology and motility functions and may participate in the regulation of neurite outgrowth and maintence of the neural network in the brain. CD314 antibodies are used in studies of cytotoxocity particularly in relation to cancer. CD314 recognizes transformed or virus-infected cells expressing CD314 ligands and thereby activated cell-mediating killing.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD314: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD314: No information.
For further information see Rosen, D. B. et al (2004) J. Immunol. 173: 2470-2478.
Database accession numbers
Revised June 25, 2008