|CD317||BST2 (bone marrow stromal cell antigen 2), HM1.24|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 2 glycoprotein
|29 / 29|
33 / 33
|CD317 is expressed by mature Ig-secreting B lymphocytes (plasma cells and lymphoplasmacytoid cells) and T lymphocytes, bone stromal cells, monocytes, NK cells, dendritic cells and neoplastic plasma cell derived from bone marrow or perpheral blood of patients with multiple myeloma or Waldenstrom's macroglobulinemia. Expression is by rheumatoid arthritis synovial cell lines and at high levels of myeloma cells lines. Expression is on fibroblasts and various normal tissues. Predominantly expression is in the liver, lung, heart, placenta and at lower levels in pancreas, kidney, skeletal muscle and brain.|
|MOLECULAR FAMILY NAME|
CD317 is a single-pass type-2 180 aa glycoprotein. It contains a 28 aa signal anchor, an 132 aa extracellular domain which contains 2 potential N-linked glycosylation sites, a transmembrane domain and a 20 aa N-terminal cytoplasmic domain.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
CD317 has 2 potential N-linked gylcosylation sites.
|LIGANDS AND MOLECULE ASSOCIATED WITH CD317: No information.|
|The function of CD317 is unclear but it might have a role in the interaction between lymphocytes and bone stromal cells has been suggested. CD317, bone marrow stromal cells, are involved in the growth and development of B-cells through their surface molecules and cytokines. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD317 IN INTACT ANIMAL
CD317 is a marker of late-stage B-cell maturation and potential target in immunotherapy of patients of multiple myeloma. A humanized mAb is being evaluated as a therapeutic agent in this context. CD317 may play a role in pre-B-cell growth and B-cell activation in rheumatoid arthritis.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD317: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD317: No information.
For further information see Goto, T. et al (1994) Blood 84: 1922-1930.
Database accession numbers
Revised June 25, 2008