CD317 BST2 (bone marrow stromal cell antigen 2), HM1.24
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 2 glycoprotein
B Lymphocyte
T Lymphocyte
Monocyte
NK Cell
Dendritic Cell
Stromal Cell
Plasma Cell
Fibroblast
Placenta
Heart
Liver
Lung
Bone Marrow
Synovial Cell
29 / 29
33 / 33

Expression
CD317 is expressed by mature Ig-secreting B lymphocytes (plasma cells and lymphoplasmacytoid cells) and T lymphocytes, bone stromal cells, monocytes, NK cells, dendritic cells and neoplastic plasma cell derived from bone marrow or perpheral blood of patients with multiple myeloma or Waldenstrom's macroglobulinemia.  Expression is by rheumatoid arthritis synovial cell lines and at high levels of myeloma cells lines.  Expression is on fibroblasts and various normal tissues.  Predominantly expression is in the liver, lung, heart, placenta and at lower levels in pancreas, kidney, skeletal muscle and brain.

Structure
MOLECULAR FAMILY NAME

CD317 is a single-pass type-2 180 aa glycoprotein.  It contains a 28 aa signal anchor, an 132 aa extracellular domain which contains 2 potential N-linked glycosylation sites, a transmembrane domain and a 20 aa N-terminal cytoplasmic domain. 

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION

CD317 has 2 potential N-linked gylcosylation sites.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD317: No information.

Function
The function of CD317 is unclear but it might have a role in the interaction between lymphocytes and bone stromal cells has been suggested.  CD317, bone marrow stromal cells, are involved in the growth and development of B-cells through their surface molecules and cytokines.  

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD317 IN INTACT ANIMAL

CD317 is a marker of late-stage B-cell maturation and potential target in immunotherapy of patients of multiple myeloma.  A humanized mAb is being evaluated as a therapeutic agent in this context.  CD317 may play a role in pre-B-cell growth and B-cell activation in rheumatoid arthritis. 


Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD317: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD317: No information.

ADDITIONAL INSIGHTS

For further information see Goto, T. et al (1994) Blood 84: 1922-1930.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 684Q10589
Antibodies

Revised June 25, 2008


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