CD320 8D6, 8D6A
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Dendritic Cell
Germinal Center
29 / 29

Expression
CD320 is expressed on follicular dendritic cells.  Expression is confined to germinal centers.

Structure
MOLECULAR FAMILY NAME: Belongs to the lipoprotein receptor family.

CD320 is a single-pass type-1 282 aa glycoprotein.  It contains a 32 aa signal sequence and a 230 aa extracellular domain which contains 2 domains with homology to type-A cysteine-rich repeats.  Each domain contains 6 cysteines with acidic residues separating the 5th and 6th cysteines.  The 2 domains are separated by an additional cysteine-rich region interrupted by a stretch of 4 proline residues.  A putative N-glycosylation site is located in the spacer region and 2 additional sites are present between the 2nd LDL-R type A domain and the transmembrane region.  CD320 also contains an 18 aa transmembrane domain and a 32 aa short cytoplasmic tail.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION:

CD320 has one putative N-linked glycosylation site.

Ligands
LIGANDS OF MOLECULE ASSOCIATED WITH CD320: No information.

Function
CD320 is involved in the follicular dendritic cell-mediated proliferation of CD27+ plasma cells in germinal centers and is functionally important in the stimulation, development of germinal centers and proliferation of B cells in tumor formation and immunoglobulin secretion.  The germinal centers differentiate into memory B and plasma cells thought interaction with T cells and follicular dendritic cells.  CD320 specific mAb can partially block proliferation of plasma cells in vitro and in vivo.  CD320 augments the proliferation of plasma cell precusors generated by IL-10.  The mechanisms involved have yet to be determined. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD320 IN INTACT ANIMAL

CD320 is a potential target of immunotherapy in the treatment of lymphomas.  It has been proposed that the CD320 signaling pathway may counter the growth of follicular lymphomas or other tumors that metastasize to lymphoid follicles.  CD320 may play a role in lymphomagenesis as proliferation of a Burkitt's lymphoma cell line which occurs in the presence of CD320+ follicular dendritic cells, but the addition of CD320-specific mAb inhibits tumor cell growth.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD320: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD320: No information.

ADDITIONAL INSIGHTS

For further information see Zhang, X. (2001) J. Immunol. 167: 49-56.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene51293Q9NPF0
Antibodies

Revised June 25, 2008


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