IL-14R high molecular weight B cell growth factor receptor
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Unknown
B Cell, Activated
Leukemia cell
B Cell, Resting Dim
45 / 90

Expression
IL-14R is expressed at a low level on resting B cells, but at high levels on activated B cells and B cell leukemias.

Structure
IL-14R cDNA clones have not been isolated yet.  However the BA5 monoclonal antibody, believed to recognize the human IL-14R, immunoprecipitates a protein of approximately 90 kDa which may consist of 2 distinct subunits.  Cross linking experiments used 125 I-labeled IL-14 also identified as an IL-14-binding protein of approximate4ly 90 kDa.

MOLECULAR MASS
Cell type Unreduced Reduced
48 and 90 kDa 48-50 kDa


Ligands
IL-14R on leukemic B cells binds IL-14 with a low affinity of kDa=20 nM.  Bb, the activation fragment of complement Factor B, completes with IL-14 for binding to the IL-14R.

Function
IL-14 induces proliferation of activated B cells and inhibits immunoglobulin secretion in B cells, levels of intracellular cAMP, diacylglycerol and calcium are increased following IL-14 binding to the IL-14R.

Comments


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
Antibodies

Revised June 25, 2008


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