|CD349||FZD9 (frizzed homolog 9), FzE6, Fz-9, hFz9,Fz-9, FZD3, Frizzed-9|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 3 glycoprotein, 7 span
|65 / 65|
|CD349 is predominantely expressed in adult and fetal brain, testis, eye, skeletal muscle and kidney. There is expression by parenchymatic cells around large vessels of the placenta, by the CFU-F forming mesenchymal stem cells of bone marrow and placenta by neural precursor cells. There is moderate expression in the pancreas, thyroid, adrenal cortex, small instestine and stomach. |
|MOLECULAR FAMILY NAME: Belongs to the G-protein coupled receptor, Frizzed family.|
CD349 is a multi-pass type-3 569 aa glycoprotein. It contains a 207 aa extracellular N-terminus domain which contains a cysteine-rich ligand-binding site, 7 transmembrane-spanning domains and a 62 aa cytoplasmic domain which contains a Lys-Thr-X-X-X-Trp motif. This motif is the binding site for PDZ-damain containing proteins and is essential for activation of the Wnt/β-catenin pathway. Most of the frizzled receptors are coupled to the β-catenin canonial signaling pathway, which leads to the activation of dishevelled proteins, inhibition of GSK-3 kinase, nuclear accumulation of β-catenin and activation of Wnt target genes. A second pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Studies suggest that CD349 may form heterodimers.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH CD349|
The CD349 domain is involved in binding with Wnt proteins including Wnt-2 and Wnt-7a.
CD349 is a marker for bone marrow and placenta mesenchymatic stem cells (MSC). CD349 is essential for the regulation of tissue and cell polarity, embryonic development, regulation of proliferation and many other processes in developing and adult organisms. CD349 participates in the activation of the Wnt/β-catenin pathway (canonical Wnt signaling) and is involved in coupling to members of the G proteins. These interactions with G-proteins may be involved in transduction and intercellular transmission of information during tissue morphogenesis and/or in differentiated tissues.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD349: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD349: No information.
Database accession numbers
Revised June 25, 2008