|CDw210b||IL10Rβ (interleukin 10 receptor β), CRFB4|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Lineage Restricted Molecule|
Type 1 glycoprotein
|37 / 37|
|CDw210β is highly expressed mainly on hematopoietic cells including T and B cells, NK cells, monocytes, macrophages and on large granular lymphocytes. Expression is in spleen, thymus and PBMC. Weak expression is in pancreas, skeletal muscle, brain, heart and kidney. Intermediate levels of expression is in placenta, lung, and liver. |
|MOLECULAR FAMILY NAME: Belongs to the type-2 cytokine receptor family.|
CDw210β is a single-pass type-1 325 aa glycoprotein. It contains an extracellular domain which contains two 100 aa fibronectin type-3 domains, a transmembrane domain and a 318 aa cytoplasmic domain. The WSXWS motif characteristic of class 1 cytokine receptors is absent from both extracellular domains. The cytokine receptor family includes CD119 (IFNgR), CD118 (IFNa/bR) , CD142 tissue factor and viral CD119 orthologues.
IL10RB and three other interferon genes, IFAR2, IFNAR1, and IFNGR2 form a class II cytokine receptor gene custer. The human IL-10R has been identified as a 90 kDa-110 kDa protein by crosslinking experiments.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
LIGANDS AND MOLECULES ASSOCIATED WITH CDw210β
|CDw210β is the receptor and binds IL-22 but does not bind IL-10 for signal transduction.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CDw210β IN INTACT ANIMAL: No information.
Database accession numbers
Revised June 25, 2008