CDw210b IL10Rβ (interleukin 10 receptor β), CRFB4
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Lineage Restricted Molecule
Type 1 glycoprotein
T Cell
B Cell
NK Cell
Monocyte
Macrophage
Lymphocyte
Thymus
Spleen
37 / 37

Expression
CDw210β is highly expressed mainly on hematopoietic cells including T and B cells, NK cells, monocytes, macrophages and on large granular lymphocytes.  Expression is in spleen, thymus and PBMC.  Weak expression is in pancreas, skeletal muscle, brain, heart and kidney.  Intermediate levels of expression is in placenta, lung, and liver. 

Structure
MOLECULAR FAMILY NAME: Belongs to the type-2 cytokine receptor family.

CDw210β is a single-pass type-1 325 aa glycoprotein.  It contains an extracellular domain which contains  two 100 aa fibronectin type-3 domains, a transmembrane domain and a 318 aa cytoplasmic domain.  The WSXWS motif characteristic of class 1 cytokine receptors is absent from both extracellular domains.  The cytokine receptor family includes CD119 (IFNgR), CD118 (IFNa/bR) , CD142 tissue factor and viral CD119 orthologues. 
IL10RB and three other interferon genes, IFAR2, IFNAR1, and IFNGR2 form a class II cytokine receptor gene custer. The human IL-10R has been identified as a 90 kDa-110 kDa protein by crosslinking experiments.

MOLECULAR MASS
Cell Type Unreduced Reduced
90 - 110 kDa

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands

LIGANDS AND MOLECULES ASSOCIATED WITH CDw210β

CDw210β binds IL-22 directly with high affinity and binding has been reported to IL-26, IL-28A and B and IL-29.  CDw210β does not bind IL-10 but the functional receptor appears to be a tetramer containing two molecules of CDw210α and 2 of CDw210β.



Function
CDw210β is the receptor and binds IL-22 but does not bind IL-10 for signal transduction.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CDw210β IN INTACT ANIMAL: No information.




Comments

MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CDw210β: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CDw210β: No information.



Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 3588Q08334
Antibodies

Revised June 25, 2008


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