ADAM28 ADAM28 (metallopeptidase domain 28)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein		Small intestine
Lymph Node
Spleen
Trachea
Stomach
Colon
Appendix
Lymphocyte

Expression
ADAM28 is expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea.  The lymphocyte population is responsible for expression of this protein in these tissues.  Isoform 2 is expressed preferentially in the spleen.  Expression is lower in peripheral blood leukocytes.

Structure
MOLECULAR FAMILY NAME: Belongs to the metalloprotease family.

ADAM28 is a single-pass type-1 540 aa glycoprotein.  It contains a signal sequence, a extracellular domain which contains a disintegrin domain, a EGF-like domain, a metalloproteinase domain and 6 potential N-linked glycosylation sites, a transmembrane and cytoplasmic domain.  ADAM28 is a member of the ADAM family, a disintegrin and metalloprotease family.  It a family of cell surface and secreted glycoproteins that posses both proteolytic and adhesive properties.  Members of this family are a membrane-anchored proteins structurally related to snake venom disintegrins.  This protein is related to other existing ADAM CD members such as CD156a (ADAM-8), CD156b (ADAM-10) and CD156c (ADAM-17).

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.  Isoform 1 is a membrane protein. and the isoform 2 is a secreted protein. 

POST-TRANSLATIONAL MODIFICATION

ADAM28 has 6 N-linked glycosylation sites.



Ligands
LIGANDS AND MOLECUES ASSOCIATED WITH ADAM28: No information

Function

ADAM28 has been implicated in a variety of cell-cell and cell-matrix interactions.  It may play a role in the adhesive and proteolytic events that occur during lymphocye surface target proteins, such as CD178 (FasL) and CD40L.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF ADAM28 IN INTACT ANIMAL

ADAM28 plays a role in sperm maturation, fertilization, muscle development and neurogenesis.



Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF ADAM28: No information

SUBSTRATES

ENZYMES WHICH MODIFY ADAM28: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene10863Q9UKQ2
Antibodies
Revised June 25, 2008


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