| AGER | AGER (advanced glycosylation end product-specific receptor), RAGE |
| Molecule Type | Antigen Expression | Molecular Weight Min / Max |
| Non-lineage Restricted Molecule Type 1 glycoprotein | Endothelial Cell |
Expression | ||||||||||||||
| AGER is expressed on endothelial cells. | ||||||||||||||
Structure | ||||||||||||||
| MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family. AGER is a single-pass type-1 glycoprotein. It contains an extracellular domain which contains 2 Ig-like C2-type domains and 1 Ig-like C2-type domain, a transmembrane domain and a cytoplasmic domain. AGER is a member of the IG superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-β protein (CD271), members of the S100/calgranulin superfamily and advanced glycation products. The gene lies within the MHV class III region on chromosome 6. MOLECULAR MASS POST-TRANSCRIPTIONAL MODIFICATION Alternative splicing yields 2 different isoforms. Isoform 1 is a membrane protein and isoform 2 is a secreted protein. POST-TRANSLATIONAL MODIFICATION: No information. | ||||||||||||||
Ligands | ||||||||||||||
| LIGANDS AND MOLECULES ASSOCIATED WITH AGER: No information. | ||||||||||||||
Function | ||||||||||||||
| AGER mediates interactions of advance glycosylation end products (CD204 molecule ligands). AGER is a receptor for amyloid-β peptide. BIOCHEMICAL ACTIVITY: No information. DISEASE RELEVANCE AND FUNCTION OF AGER IN INTACT ANIMAL AGER is a nonenzymatically glycosylated protein which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. | ||||||||||||||
Comments | ||||||||||||||
| MOLECULAR INTERACTION- PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF AGER: No information. SUBSTRATES: No information. ENZYMES WHICH MODIFIY AGER: No information. | ||||||||||||||
Database accession numbers | ||||||||||||||
Revised June 25, 2008
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