AGER AGER (advanced glycosylation end product-specific receptor), RAGE
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Endothelial Cell

Expression
AGER is expressed on endothelial cells.

Structure
MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family.

AGER is a single-pass type-1 glycoprotein.  It contains an extracellular domain which contains 2 Ig-like C2-type domains and 1 Ig-like C2-type domain, a transmembrane domain and a cytoplasmic domain.  AGER is a member of the IG superfamily of cell surface molecules.  It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-β protein (CD271), members of the S100/calgranulin superfamily and advanced glycation products.  The gene lies within the MHV class III region on chromosome 6.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.  Isoform 1 is a membrane protein and isoform 2 is a secreted protein.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH AGER: No information.

Function
AGER mediates interactions of advance glycosylation end products (CD204 molecule ligands). AGER is a receptor for amyloid-β peptide. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF AGER IN INTACT ANIMAL

AGER is a nonenzymatically glycosylated protein which accumulate in vascular tissue in aging and at an accelerated rate in diabetes.


Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF AGER: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFIY AGER: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 177Q15109
Antibodies

Revised June 25, 2008


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