|AGER||AGER (advanced glycosylation end product-specific receptor), RAGE|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|AGER is expressed on endothelial cells.|
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family.|
AGER is a single-pass type-1 glycoprotein. It contains an extracellular domain which contains 2 Ig-like C2-type domains and 1 Ig-like C2-type domain, a transmembrane domain and a cytoplasmic domain. AGER is a member of the IG superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-β protein (CD271), members of the S100/calgranulin superfamily and advanced glycation products. The gene lies within the MHV class III region on chromosome 6.
Alternative splicing yields 2 different isoforms. Isoform 1 is a membrane protein and isoform 2 is a secreted protein.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH AGER: No information.|
|AGER mediates interactions of advance glycosylation end products (CD204 molecule ligands). AGER is a receptor for amyloid-β peptide. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF AGER IN INTACT ANIMAL
AGER is a nonenzymatically glycosylated protein which accumulate in vascular tissue in aging and at an accelerated rate in diabetes.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF AGER: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFIY AGER: No information.
Database accession numbers
Revised June 25, 2008