AOC3 AOC3 (amine oxidase, copper containing 3 (vascular adhesion protein 1)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 2 glycoprotein
Lymph Node
Endothelia
Lung
Appendix
Small intestine

Expression
AOC3 is strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia.  Expression is also in appendix, lung and small intestine but in lower levels in bone marrow, colon, heart, heart, kidney, ovary, panreas, placenta, prostate, skeletal muscle, spleen and testis.

Structure
MOLECULAR FAMILY NAME:  Belongs with the copper/toaquinone oxidase family.

AOC3 is a single-pass type-2 763 aa glycoprotein.  It contains a signal sequence, an extracellular domain which contains N-linked and O-linked glycosylation sites, a transmembrane domain and a cytoplasmic domain.  AOC3 is a major protein on the adipocyte plasma membrane.  AOC3 binds 1 copper ion per subunit, 2 calcium ions per subunit and contains 1 topaquinone per subunit.  Topaquinone is generated by copper-dependent autoxidation of a specific tyrosyl residue.  AOC3 is a homodimer and is disulfide linked.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION

AOC3 has N- and O-linked glycosylation sites.

Ligands
LIGAND AND MOLECULES ASSOCIATED WITH AOC3No information.

Function
Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone.  AOC3 is a cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in a L-selecin independent fashion.  AOC3 has adhesive properties and has functional a monoamine oxidase activity.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF AOC3 IN INTACT ANIMAL:No information.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNE ELEMENTS WHICH REGULATE TRANSCRIPTION OF AOC3: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY AOC3: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 8639Q16853
Antibodies

Revised June 25, 2008


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