|APOB48R||APOB48R (apolipoprotein B48 receptor)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
APOB48R is expressed by reticuloendothelial cells such as monocytes, macrophages and endothelial cells. It is expressed in all but skeletal muscle, with highest expression is in lung and placenta, and less in brain and heart.
|MOLECULAR FAMILY NAME|
APOB48R is a 1,088 aa protein with no known homology.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH APOB48R: No information.|
|APOB48R is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction and atherothrombogenesis.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF APOB48R IN INTACT ANIMAL
APOB48R is in foam cells of human atherosclerotic lesions.
|MOLECULAR INTERACTION- |
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF APOB48R: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY APOB48R: No information.
Database accession numbers
Revised June 25, 2008