CD66f PSG1(pregnancy-specific β-1 glycoprotein 1), Sp-1
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Glycoprotein
Myeloid Cell
Liver
Syncytiotrophoblast
Placenta
Serum
54 / 54
72 / 72

Expression
CD66f is expressed on placental syncytiotrophoblasts and detected in maternal serum, fetal liver, myeloid cell lines and produced in placenta and then released.



Structure
MOLECULAR FAMILY NAME:  Belongs to the carcinomebryonic antigen gene family.

CD66f is a glycoprotein.  It contains a 34 aa leader sequence, a 286 aa or 378 aa extracellular domain which contains 2 or 3 Ig-like C2-type domains and 1 Ig-like V-type domain followed by short hydrophilic sequences of 2 aa-13 aa.  The CEA family belongs within the Ig superfamily.

MOLECULAR MASS
Cell Type Unreduced Reduced Comment
Found in serum 54-72 kDa

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 4 different isoforms.  Many spliced isoforms are from 11 highly conserved PSG genes.

POST-TRANSLATIONAL MODIFICATION

CD66f is heavily and variably N-glycosylated with 4-8 N-glycosylation sites.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD66f: No Information.    

Function
BIOCHEMICAL ACTIVITY

The function of CD66f is unclear but most species contain a RGD motif.

DISEASE RELEVANCE AND FUNCTION OF CD66f IN INTACT ANIMAL:

The function of CD66f is unclear but low levels in maternal blood predict spontaneous abortion.  CD66f may protect the fetus from maternal immune system which is necessary for a successful pregnancy.

Comments
The CEA family in humans and other mammals.
The human CEA molecules are a family of closely related, IgSF domain-containing glycoproteins encoded by a dense cluster of at least 18 genes within ~1.2 Mb with a 65%-75% sequence identity.  Based on sequence similarity and gene proximity this family can be divided into 2 subgroups, with a 80%-95% sequence identity within each subgroup. The CEA subgroup,  >7 genes, encodes predominantly cell surface molecules, whereas the pregnancy-specific glycoprotein (PSG) subgroup,  >11 genes, encodes secreted molecules.  CEA and PSG subgroups have also been identified in the mouse and the rat.  However, molecules within the subgroups show greater intraspecies,  >80%, than interspecies,  ~60% identity, making it impossible to identify species orthologues.  Indeed orthologues may not exist since sequence analysis suggests that there has been independent and parallel evolution of the CEA and PSG subgroups following the divergence of rodents and humans.

MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD66f: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD66f: No information.

ADDITIONAL INSIGHTS

The data are consistent with the hypothesis that CD66f may protect the fetus from the maternal immune system.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 5669P11464
Antibodies

Revised June 25, 2008


Contact us: Webmaster |  509-335-9515 | Accessibility | Copyright | Policies
College of Veterinary Medicine Washington State University, Pullman, WA, 99164-7010 USA
Copyright 1995-2003 Washington State University