|BENE||Bene, Mall (mall, T cell differentiation protein-like)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|BENE is expressed on endothelial-like ECV304 cells lines and normal human endothelium. Expression is in renal epithelial, cervical carcinoma but not in T cell, liver, kidney cell lines.|
|MOLECULAR FAMILY NAME: Belongs to the MAL family.|
BENE is a multi-pass 153 aa membrane protein. It contains a MARVEL domain and 3 consensus caveolin-1 interaction motifs. BENE is a gene which encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid- and cholesterol-enriched membrane (GEM) rafts. It interacts with caveolin.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST TRANSLATIONAL MODIFICATION: No infirmation.
|LIGANDS AND MOLECULES ASSOCIATED WITH BENE: No information.|
BENE with caveolin-1 (CAV1) and CD59 displays intracellular colocalization in the Golgi region and an interactions with CAV1 in solubilized glycolipid- and cholesterol-enriched membrane (GEM) rafts . In response to cell surface cholesterol oxidation, BENE redistributed to dilated vesicular structures where most CAV1 originally on the cell surface was concentrated. The BENE proteolipid is an element of the machinery for raft-mediated trafficking in endothelial cells.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF BENE: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY BENE: No information.
Database accession numbers
Revised June 25, 2008