BENE Bene, Mall (mall, T cell differentiation protein-like)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Unknown
Endothelial Cell
Endothelium
Carcinoma Cell
Epithelial Cell

Expression
BENE is expressed on endothelial-like ECV304 cells lines and normal human endothelium.  Expression is in renal epithelial, cervical carcinoma but not in T cell, liver, kidney cell lines.

Structure
MOLECULAR FAMILY NAME: Belongs to the MAL family.

BENE is a multi-pass 153 aa membrane protein.  It contains a MARVEL domain and 3 consensus caveolin-1 interaction motifs.   BENE is a gene which encodes an element of the machinery for raft-mediated trafficking in endothelial cells.  The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid- and cholesterol-enriched membrane (GEM) rafts.  It interacts with caveolin.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST TRANSLATIONAL MODIFICATION: No infirmation.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH BENE: No information.

Function

BENE with caveolin-1 (CAV1) and CD59 displays intracellular colocalization in the Golgi region and an interactions with CAV1 in solubilized glycolipid- and cholesterol-enriched membrane (GEM) rafts .  In response to cell surface cholesterol oxidation, BENE redistributed to dilated vesicular structures where most CAV1 originally on the cell surface was concentrated.  The BENE proteolipid is an element of the machinery for raft-mediated trafficking in endothelial cells.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF BENE IN INTACT ANIMAL: No information.



Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF BENE: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY BENE: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 7851Q13021
Antibodies

Revised June 25, 2008


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