|C3X1||CX3CR1 (chemokine (C-X3-C motif) receptor 1)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|C3X1 is expressed in lymphoid and neural tissues. Northern blot analysis showed expression is high in brain, peripheral blood leukocytes, spleen and myeloid cells but no expression lymphoid cell lines.|
|MOLECULAR FAMILY NAME: Belongs to the G-protein coupled receptor 1 family.|
C3X1 is a multi pass glycoprotein. It contains an extracellular domain, a 20 aa 7 putative transmembrane domains and a cytoplasmic domain.
Alternative splicing yields 3 different isoforms.
POST-TRANSLATIONAL MODIFICATION: No information.
| LIGANDS AND MOLECULES ASSOCIATED WITH C3X1: No information.|
|Fractalkine (CX3CR1) with a C3X1 motif chemokine atop a mucin stalk, induces both adhesion and migration of leukocytes. The receptor, CX3CL1, requires pertussis toxin sensitive G protein signaling to induce migration but not to support adhesion which occurs without other adhesion molecules but requires the architecture of a chemokine domain atop the mucin stalk. NK cells express CX3CR1 and respond to fractalkine in both migration and adhesion. It has been concluded that fractalkine and CX3CR1 represents new type of leukocyte trafficking regulators, performing both adhesive and chemotactic functions.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF C3X1 IN INTACT ANIMAL
Variations in C3X1 are associated with rapid progression of AIDS. Increased susceptibility to HIV infection and rapid progression to AIDS are associaed with the Ile-249/Met-280 haplotype. C3X1 acts as a coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV coreceptors than isoform 1.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF C3X1: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY C3X1: No information.
Database accession numbers
Revised June 25, 2008