CLC CLC (charcot-leyden crystal protein)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Unknown
Basophil
Eosinophil

Expression
CLC is expressed exclusively by eosinophils and basophils but not in monocytes and neutrophils.

Structure
MOLECFULAR FAMILY NAME

CLC shows similarities to members of the superfamily of β-galactoside binding S-type animal lectins.  CLC may possess carbohydrate or IgE binding activities.  CLC contains 1 galectin domain and is localized in granules from where it may be secreted or transported to other locations in the cell.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CLC: No information.

Function
Lysophospholipases are an enzyme that act on the biological membrane to regulate the multifunctional lysophospholipase.  CLC encoded by this gene is a lysophospholipase and it hydrolyzes lysophosphatidylcholine to glycerophosphocline and a fatty acid.  It is both structurally and functionally related to the galectin family of β-galactoside binding proteins.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CLC IN INTACT ANIMAL

CLC may be associated wiht inflammation and some myeloid leukemias.  CLC forms hexagonal bypyramidal crystals, known as Charcot-Leyden crystals, in tissues and secretions from the sites of eosinophils-associated inflammation and some myeloid leukemias.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIKPTION OF CLC: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CLC: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 1178Q05315
Antibodies

Revised June 25, 2008


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