|CLC||CLC (charcot-leyden crystal protein)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|CLC is expressed exclusively by eosinophils and basophils but not in monocytes and neutrophils.|
|MOLECFULAR FAMILY NAME|
CLC shows similarities to members of the superfamily of β-galactoside binding S-type animal lectins. CLC may possess carbohydrate or IgE binding activities. CLC contains 1 galectin domain and is localized in granules from where it may be secreted or transported to other locations in the cell.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH CLC: No information.|
|Lysophospholipases are an enzyme that act on the biological membrane to regulate the multifunctional lysophospholipase. CLC encoded by this gene is a lysophospholipase and it hydrolyzes lysophosphatidylcholine to glycerophosphocline and a fatty acid. It is both structurally and functionally related to the galectin family of β-galactoside binding proteins.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CLC IN INTACT ANIMAL
CLC may be associated wiht inflammation and some myeloid leukemias. CLC forms hexagonal bypyramidal crystals, known as Charcot-Leyden crystals, in tissues and secretions from the sites of eosinophils-associated inflammation and some myeloid leukemias.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIKPTION OF CLC: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CLC: No information.
Database accession numbers
Revised June 25, 2008