CLEC1A CLEC1A (C-type lectin domain family member A), CLEC1
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 2 glycoprotein
Dendritic Cell
Placenta
Lung

Expression

CLEC1A is expressed by Northern blot analysis revealed expression was strong in placenta and lung, moderate expression in thymus and heart and weak in other tissues.  RT-PCR analysis detected high levels of expression in dendritic cells activated TNF or CD154 but weak expression in monocytes and no expression in granulocytes and lymphocytes.



Structure

MOLECULAR FAMILY NAME: Belongs to the C-type lectin domain family.

CLEC1A is a single-pass type-2 280 aa glycoprotein.  It contains an extracellular domain which contains 1 C-type lectin domain, a single carbohydrate recognition domain which lacks the amino acids necessary for calcium-dependent carbohydrate binding and 6 conserved and 2 additional cysteine residues, a transmembrane domain and a cytoplasmic domain which has an immunoreceptor tyrosine-based motif (YSST) and several potential phosphorylation sites.  Flow cytometric analysis demonstrated intracellular expression in CLEC1-transfected cells suggesting the requirement of an additional molecule to form a heterodimer expressed on the cell surface is needed as observed by CD159a (NKG2A and CD159c (NKG2C).  CLEC1A is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex (NKC) region.  NKC may encode C-type lectin-like receptors expressed not only in NK cells but also in other cells and at least one of these is of potential importance in regulating dendritic cell function.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION:

Alternative splice isoforms have been described but their biological nature has not been determined.

POST-TRANSLATIONAL MODIFICATION: No information.



Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CLEC1A: No information.

Function
CLEC1A encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily.  Members of this family share a common protein fold and have diverse functionsm such as cell adhesion, cell-cell signaling, glycoprotein turnover and roles in inflammation and immune responses.  The encoded protein may play a role in regulating dendritic cell function.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CLEC1A IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CLEC1A: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CLEC1A: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene51267Q8NC01
Antibodies

Revised June 25, 2008


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