CLEC4A CLEC4A (C-type lectin domain family 4, member A), CLECSF6
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Lineage Restricted Molecule
Type 2 glycoprotein
Dendritic Cell
Neutrophil
Myeloid Cell
B Cell
Leukocyte
Peripheral blood
Granulocyte
Monocyte
Macrophage
Hematopoietic tissue

Expression

CLEC4A is expressed in dendritic cells, myeloid cells, B cells, HL-60 cells, TNF-α, LPS and down regulated expression at the surface of neutrophils at the protein level.  Preferentially, expression is in hematopoietic tissues, peripheral blood leukocytes, moderate levels in spleen, lymph node and bone marrow and low levels in thymus.  Expression is also in antigen presenting cells such as monocytes, macrophages and graulocytes.  Expression is decreased in dendritic cells by signals inducing its maturation (e.g. CD40 ligand, LPS and TNF-α).



Structure
MOLECULAR FAMILY NAME: Belongs to the C-type lectin superfamily.

CLEC4A is a single-pass type-2 213 aa glycoprotein.  It contains an extracellular domain which contains a stalk domain, 1 C-type carbohydrate recognition domain (CRD), 3 potential N-glycosylation sites and 1 conserved calcium binding site that contains a mannose-binding EPN motif, a transmembrane and a N-terminal cytoplasmic domain which contains a phosphorylated immunoreceptor tyrosine inhibitor motif (ITIM) which is invovled in cellular responses and can bind the SH2 domain of several SH2 containing phosphatases.  CLEC4A is closely linked to other C-type lectins on chromosome 12p13 in the natural killer gene complex.

MOLECULAR MASS

POST-TRANSCRIPTION MODIFICATION

Alternative splicing yields 4 different isoforms.

POST-TRANSLATION MODIFICATION

CLEC4A has 3 potential gylcosylation sites.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CLEC4A: No information.

Function
Members of this lectin-like family share a common protein fold and have diverse functions such as cell adhesion, cell-cell signaling, glycoprotein turnover and roles in inflammation and immune response.  CLEC4A may be involved in regulating immune reactivity, in modulating dendritic cell differentiation and/or maturation and may be involved via its ITIM motif in the inhibition of B cell receptor mediated calcium mobilization and protein tyrosine phosphorylation.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CLEC4A IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CLEC4A: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CLEC4A: No information,

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene50856Q9UMR7
Antibodies

Revised June 25, 2008


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