|CLEC5A||CLEC5A (C-type lectin domain family, 5)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 2 glycoprotein
|CLEC5A is expressed in peripheral blood monocytes, in monocyte/macrophage cell lines U937 and MonoMac6 but not in cell lines of other origins. Expression is down regulated when monocytes differentiate into dendritic cells.|
|MOLECULAR FAMILY NAME: Belongs to the C-type lectin superfamily.|
CLEC5A is a single-pass type-2 187 aa glycoprotein. It contains an extracellular domain which contains a C-type lectin domain and a putative N-linked glycosylation site, a transmembrane domain which contains a positively charged amino acid that enables it to pair with dnax-activation protein 12 (Dap12) and a short 2 aa intracellular cytoplasmic domain.
Alternative splicing yields 2 different isoforms. The isoforms have been decribed but their full length has not been determined.
CLEC5A has a glycosylation site.
|LIGANDS AND MOLECULES ASSOCIATED WITH CLEC5A: No information.|
|Members of this lectin-like family share a common protein fold and have diverse functions such as cell adhesion, cell-cell signaling, glycoprotein turnover and roles in inflammation and immune response. CLCE5A interacts with Dap12 and may play a role in cell activation. CLEC5A may be involved in proinflammatory activation of myeloid cells by tyrosine kinase-binding protein (TYROBP)-mediating signaling in a calcium-dependent manner.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CLEC5A IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CLEC5A: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CLEC5A: No information.
Database accession numbers
Revised June 25, 2008