CLEC7A CLEC7A (C-type lectin domain, member A), CLECSF12, Dectin 1
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Lineage Restricted Molecule
Type 2 glycoprotein
Leukocyte
Dendritic Cell
Monocyte
Peripheral blood
Spleen
Lung
Skeletal muscle
Stomach
Placenta
Bone Marrow
33 / 33

Expression
CLEC7A is expressed highly in peripheral blood leukocytes and dendritic cells.  Expression is also in spleen, bone marrow, lung, muscle, stomach and placenta.  CLEC7A is upregulated during the differentiation from monocytes into dendritic cells.

Structure

MOLECULAR FAMILY NAME: Belongs to the C-type lectin superfamily.

CLEC7A is a single-pass type-2 247 aa glycoprotein.  It contains an extracellular domain which contains a C-type lectin domain, a transmembrane domain and a cytoplasmic domain which contains an immunoreceptor tyrosine-based activation motif.  CLEC7A is closely linked to other lectin family members on chromsome 12p13 in the natural killer gene complex domain.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 8 different isoforms.

POST-TRANSLATIONAL MODIFICATION

CLEC7A is  phosphorylated ontyrosine residues in response to glucan binding.



Ligands

LIGANDS AND MOLECULES ASSOCIATED WITH CLEC7A: No information.



Function

Lectin functions as a pattern specific β-1, 3-linked and β-1, 6-linked glucans, such as well as cell wall constituents from pathogenic bacteria and fungi and in  this way plays role in innate immune response.  It is necessary for the TLR2-mediated inflammatory response and the TLR2-mediated activation of NF-κB.  Enhancement of cytokine production occurs in macrophages and dendritic cells. CLEC7A mediates the production of reactive oxygen species in the cell and the phagocytosis of C-albicans conidia.  It binds T cells in a way that does not involve their surface glycans and plays a role in T cell activation and stimulates T cell proliferation.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CLEC7A ON INTACT ANIMAL: No information.



Comments

MOLECULAR INTERACTION-
PROTEINS AND DRN ELEMENTS WHICH REGULATE TRANSCRIPTION OF CLEC7A: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CLEC7A: No information.



Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene64581Q9BXN2
Antibodies

Revised June 25, 2008


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