|CLEC7A||CLEC7A (C-type lectin domain, member A), CLECSF12, Dectin 1|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Lineage Restricted Molecule|
Type 2 glycoprotein
|33 / 33|
|CLEC7A is expressed highly in peripheral blood leukocytes and dendritic cells. Expression is also in spleen, bone marrow, lung, muscle, stomach and placenta. CLEC7A is upregulated during the differentiation from monocytes into dendritic cells.|
MOLECULAR FAMILY NAME: Belongs to the C-type lectin superfamily.
LIGANDS AND MOLECULES ASSOCIATED WITH CLEC7A: No information.
Lectin functions as a pattern specific β-1, 3-linked and β-1, 6-linked glucans, such as well as cell wall constituents from pathogenic bacteria and fungi and in this way plays role in innate immune response. It is necessary for the TLR2-mediated inflammatory response and the TLR2-mediated activation of NF-κB. Enhancement of cytokine production occurs in macrophages and dendritic cells. CLEC7A mediates the production of reactive oxygen species in the cell and the phagocytosis of C-albicans conidia. It binds T cells in a way that does not involve their surface glycans and plays a role in T cell activation and stimulates T cell proliferation.
Database accession numbers
Revised June 25, 2008