|SRCL||COLEC12 (collectin sub-family member 12), SRCL (scavenger receptor with C-type lectin )|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 2 glycoprotein
|82 / 82|
|SRCL is expressed at high levels in placenta, lung, heart, and small intestine. Moderate expression was found in several other tissues but it was below the level of detection in liver and spleen. Expression was also found in most vascular endothelial cells in all murine vessels and human heart sections but was not detected in macrophages, monocytes and hepatic Kupffer cells.|
|MOLECULAR FAMILY NAME: Belong to the C-type lectin family.|
SRCL is a single-pass type-2 glycoprotein. It contains an extracellular domain which contains a N-terminal elucine zipper domain, a coiled- coil domain, a collagen domain, a C-type lectin/carbohydrate recognition domain (CRD) located at the C terminus, several putative N-linked glycosylation sites, transmembrane domain and a cytoplasmic domain which contains a serine/threonine-rich region.
Alternative splicing yields 2 different isoforms. Cloning showed one isoform that did not contain the C-type CRD motif.
SRCL has several putative N-linked glycoslation sites.
|LIGANDS AND MOLECULES ASSOCIATED WITH SRCL: No information.|
|SRCL (alternative name collectin) is a scavenger receptor, a cell surface glycoprotein that can bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. These receptors can recognize oxidized phospholipids so they may also participate in removing oxidatively damaged or apoptotic cells. It is thought that SRCL is a novel bacteria-binding receptor containing a C-type CRD and this receptor may play an important role in host defense.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF SRCL IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF SRCL: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY SRCL: No information.
Database accession numbers
Revised June 25, 2008