SRCL COLEC12 (collectin sub-family member 12), SRCL (scavenger receptor with C-type lectin )
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 2 glycoprotein
Placenta
Lung
Heart
Small intestine
Endothelial Cell
82 / 82

Expression
SRCL is expressed at high levels in placenta, lung, heart, and small intestine.  Moderate expression was found in several other tissues but it was below the level of detection in liver and spleen.  Expression was also found in most vascular endothelial cells in all murine vessels and human heart sections but was not detected in macrophages, monocytes and hepatic Kupffer cells.

Structure
MOLECULAR FAMILY NAME: Belong to the C-type lectin family.

SRCL is a single-pass type-2 glycoprotein.  It contains an extracellular domain which contains a N-terminal elucine zipper domain, a coiled- coil domain, a collagen domain, a C-type lectin/carbohydrate recognition domain (CRD) located at the C terminus, several putative N-linked glycosylation sites, transmembrane domain and a cytoplasmic domain which contains a serine/threonine-rich region. 

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.  Cloning showed one isoform that did not contain the C-type CRD motif.

POST-TRANSLATIONAL MODIFICATION

SRCL has several putative N-linked glycoslation sites.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH SRCL: No information.

Function
SRCL (alternative name collectin) is a scavenger receptor, a cell surface glycoprotein that can bind to carbohydrate antigens on microorganisms facilitating their recognition and removal.  These receptors can recognize oxidized phospholipids so they may also participate in removing oxidatively damaged or apoptotic cells.  It is thought that SRCL is a novel bacteria-binding receptor containing a C-type CRD and this receptor may play an important role in host defense.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF SRCL IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF SRCL: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY SRCL: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
Human
Human
Antibodies

Revised June 25, 2008


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