|CXADR||CXADR (coxsackie virus and adenovirus receptor)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|39 / 39|
|CXADR expression in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitoulsy expressed and isoform 3 is expressed in heart, lung and pancreas. Expression is not found in kidney, placenta, peripheral blood leukocytesm thymus and spleen. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.|
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family.|
CXADR is a single-pass type-1 365 aa glycoprotein. It contains a signal sequence, an extracellular domain which contains 2 Ig-like C2-type domains which probably mediates homodimerization and interaction with JAML, 2 disulfide-bonded loops resembling the characteristic Ig-like V-type and C2-type domains, 2 N-linked glycosylation sites, a transmembrane domain and a cytoplasic domain. CXADR is a protein for group B coxsackieviruses and a subgroup C adenoviruses.
Alternative splicing yields 5 different isoforms. Isoforms 1 and 2 are cell membranes and isoforms 3, 4 and 5 are secreted proteins.
CXADR has 2 N-linked glycosylation sites.
|LIGANDS AND MOLECULES ASSOCIATED WITH CXADR: No information.|
|CXADR is a component of the epithelial apical junction complex that is essential for tight junction integrity. It is proposed to function as a homophilic cell adhesion molecule and is probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN. CXADR is the receptor for group B coxsackieviruses and subgroup C of adenoviruses and the susceptibilty to infection is correlated to its level of expression and avilability at the plasma membrane of cells.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CXADR IN INTACT ANIMAL
It is thought that coxsackie virus B and the adenovirus receptor is involved in myocarditis and dilated cardiomyopathy which are common causes of morbidity and mortality in children.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CXADR: No information.
SUBSTRATES; No information.
ENZYMES WHICH MODIFY: No information.
Database accession numbers
Revised June 25, 2008