CXCL16 CXCL16 (chemokine (C-X-C motif) ligand 16
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
T Cell
Spleen
Kidney
Lung
Small intestine
Thymus
Lymph Node

Expression
CXCL16 is expressed in T cells, spleen, lymph nodes, lung, kidney, small intestine and thymus.  Expression is weak in heart and liver but no expression in brain and bone marrow.

Structure
MOLECULAR FAMILY NAME: Belongs to the chemokine C-X-C family.

CXCL16 is a single-pass type-1 273 aa glycoprotein.  It contains an extracellular domain, a transmembrane domain and a cytoplasmic domain which has a potential tyrosine phosphorylation and SH2 protein binding domain.  CXCL16  has a mucin like spacer domain.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION

CXXL16 is glycosylated.

Ligands
LIGANDS AND MOLECULES ASSOICATED WITH CXCL16: No information.

Function
CXCL16 acts as a scavenger receptor on macrophages, which specifically binds to oxidized low density lipoprotein (OxLDL) suggesting that it may be involved in pathophysiology such as atherogenesis.  CXCL16 induces a strong chemotactic response, induces calcium mobilization and binds to CXCL6/Bonzo.

BIOCHEMICAL ACTIVITY : No information.

DISEASE RELEVANCE AND FUNCTION OF CXCL16 IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CXCL16: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CXCL16: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene58191Q9H2A7
Antibodies

Revised June 25, 2008


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