|CXCL16||CXCL16 (chemokine (C-X-C motif) ligand 16|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|CXCL16 is expressed in T cells, spleen, lymph nodes, lung, kidney, small intestine and thymus. Expression is weak in heart and liver but no expression in brain and bone marrow.|
|MOLECULAR FAMILY NAME: Belongs to the chemokine C-X-C family.|
CXCL16 is a single-pass type-1 273 aa glycoprotein. It contains an extracellular domain, a transmembrane domain and a cytoplasmic domain which has a potential tyrosine phosphorylation and SH2 protein binding domain. CXCL16 has a mucin like spacer domain.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
CXXL16 is glycosylated.
|LIGANDS AND MOLECULES ASSOICATED WITH CXCL16: No information.|
|CXCL16 acts as a scavenger receptor on macrophages, which specifically binds to oxidized low density lipoprotein (OxLDL) suggesting that it may be involved in pathophysiology such as atherogenesis. CXCL16 induces a strong chemotactic response, induces calcium mobilization and binds to CXCL6/Bonzo.|
BIOCHEMICAL ACTIVITY : No information.
DISEASE RELEVANCE AND FUNCTION OF CXCL16 IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CXCL16: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CXCL16: No information.
Database accession numbers
Revised June 25, 2008