|EDG1||EDG1 (endothelial differentiation, sphingolipid G-protein-coupled receptor 1)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|EDG1 is expressed on endothelial cells and to a lesser extent expression is in vascular smooth muscle cells, fibroblasts, melanocytes and cells of epithelioid origin.|
|MOLECULAR FAMILY NAME: Belongs to the G-protein coupled receptor family.|
EDG1 is a multi-pass 380 aa glycoprotein. It contains an extracellular domain, 7 putative transmembrane domain and a cytoplasmic domain.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH EDG1: No information.|
|EDG1 is a receptor for the lysosphingolipid sphingosine 1-phosphate (SIP) which is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This G-protein coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion and seems to be coupled to the G(i) subclass of heteromeric G proteins.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF EDG1 IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF EDG1: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY EDG1: No information.
Database accession numbers
Revised June 25, 2008