EDG1  EDG1 (endothelial differentiation, sphingolipid G-protein-coupled receptor 1)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Multi-pass
Endothelial Cell

Expression
EDG1 is expressed on endothelial cells and to a lesser extent expression is in vascular smooth muscle cells, fibroblasts, melanocytes and cells of epithelioid origin.

Structure
MOLECULAR FAMILY NAME: Belongs to the G-protein coupled receptor family.

EDG1 is a multi-pass 380 aa glycoprotein.  It contains an extracellular domain, 7 putative transmembrane domain and a cytoplasmic domain.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH EDG1: No information.

Function
EDG1 is a receptor for the lysosphingolipid sphingosine 1-phosphate (SIP) which is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.  This G-protein coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells.  Activation of this receptor induces cell-cell adhesion and seems to be coupled to the G(i) subclass of heteromeric G proteins.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF EDG1 IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF EDG1: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY EDG1: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene1901P21453
Antibodies

Revised June 25, 2008


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