EDG2 EDG2 (endothelial differentiation, lysophosphatidic acid G protein coupled receptor 2)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Multi-pass
Brain
Heart
Colon
Small intestine
Placenta
Prostate
Ovary
Pancreas
Testis
Spleen
Skeletal muscle
Kidney

Expression
EDG2 expression is in many adult organs including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle and kidney.  Little or no expression is in liver, lung, thymus or peripheral blood leukocytes.

Structure
MOLECULAR FAMILY NAME:  Belongs to the G-protein coupled receptor family.

EDG2 is a multi-pass 364 aa glycoprotein.  It contains an extracellular domain, 7 transmembrane domains and a cytoplasmic domain.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.  The isoforms encodes identical proteins. 

POST-TRANSLATIONAL MODIFICATION

An alternate translation start codon has been identified, which results in isoforms differing in the N-terminal extracellular domain.  Also an alternate polyadenylation site has been reported.

Ligands
LIGANDS AND MOLECULES ASSOCIATE WITH EDG2: No information.

Function

EDG2 is a lysophosphatidic acid (LPA) receptor and a member of the G protein coupled receptor superfamily.  
 
BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF EDG1 IN INTACT ANIMAL

Utilized by LPA for cell signaling, EDG receptors mediate diverse biological functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis and tumor cell invasion. 



Comments

MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF EDG1: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY EDG2: No information.



Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene1902Q92633
Antibodies

Revised June 25, 2008


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