EDG3 EDG3 (endothelial differentiation, sphingolipid G protein coupled receptor)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Multi-pass
Heart
Placenta
Kidney
Liver

Expression
EDG3 is expressed in all tissues but most abundantly in heart, placenta, kidney and liver.

Structure
MOLECULAR FAMILY NAME: Belongs to the G-protein coupled receptor family.

EDG3 is a multi-pass glycoprotein.  It contains an extracellular domain,  7 hydrophobic transmembrane domains which are connected by hydrophilic intra- and extracellular loops and a cytoplasmic domain.  EDG3 has a 52% sequence similarity to EDG1.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands

LIGANDS AND MOLECULES ASSOCIATED WITH EDG3: No information.



Function
EDG3 is a receptor encoding the EDG family for the lysosphingolipid sphingosine 1-phosphate (SIP).  SIP is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cell and tissues.  EDG3 likely controbutes to the regulation of angiogenesis and vascular endothelial cell function.  When expressed in rat HTC4 hepatoma cells is capable of mediating SIP-induced cell proliferation and suppression of apoptosis.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF EDG3 IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF EDG3: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY EDG3: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 1903Q99500
Antibodies

Revised June 25, 2008


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