|EDG3||EDG3 (endothelial differentiation, sphingolipid G protein coupled receptor)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|EDG3 is expressed in all tissues but most abundantly in heart, placenta, kidney and liver.|
|MOLECULAR FAMILY NAME: Belongs to the G-protein coupled receptor family.|
EDG3 is a multi-pass glycoprotein. It contains an extracellular domain, 7 hydrophobic transmembrane domains which are connected by hydrophilic intra- and extracellular loops and a cytoplasmic domain. EDG3 has a 52% sequence similarity to EDG1.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
LIGANDS AND MOLECULES ASSOCIATED WITH EDG3: No information.
|EDG3 is a receptor encoding the EDG family for the lysosphingolipid sphingosine 1-phosphate (SIP). SIP is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cell and tissues. EDG3 likely controbutes to the regulation of angiogenesis and vascular endothelial cell function. When expressed in rat HTC4 hepatoma cells is capable of mediating SIP-induced cell proliferation and suppression of apoptosis.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF EDG3 IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF EDG3: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY EDG3: No information.
Database accession numbers
Revised June 25, 2008