EDG5 EDG5 (endothelial differentiation, sphingolipid G-protein coupled receptor)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Multi-pass
Brain

Expression
EDG5 expression in the rat is higher in brain embryogenesis than during later periods of brain development.

Structure

MOLECULAR FAMILY NAME: Belongs to the G-protein coupled receptor family.

EDG5 is a multi-pass 353 aa glycosylation.  It contains an extracellular domain, a transmembrane domain and a cytoplasmic domain.  EDG5 shares a 92% amino acid identity with rat H218, a 44% with human EDG1 and EDG4 and a 34% idenity with the LPA receptors EDG2 and EDG4.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.



Ligands

LIGANDS AND MOLECULES ASSOCIATED WITH EDG5: No information.



Function
EDG5 is a receptor for the lysosphingolipid sphingosine 1-phosphate (S1P).  S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.  When expressed in rat HTCA hepatoma cells, EDG5 is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.   EDG5 participates in S1P-induced cell proliferation, survival and transcriptional activation.   EDG5 may be both intracellular as a second messenger and extracellular as a receptor ligand.  S1P and LPA signals cells through the EDG receptors.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF EDG5 IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF EDG5: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY EDG5: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 9294Q95136
Antibodies

Revised June 25, 2008


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