|EDG5||EDG5 (endothelial differentiation, sphingolipid G-protein coupled receptor)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|EDG5 expression in the rat is higher in brain embryogenesis than during later periods of brain development.|
MOLECULAR FAMILY NAME: Belongs to the G-protein coupled receptor family.
LIGANDS AND MOLECULES ASSOCIATED WITH EDG5: No information.
|EDG5 is a receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTCA hepatoma cells, EDG5 is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. EDG5 participates in S1P-induced cell proliferation, survival and transcriptional activation. EDG5 may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and LPA signals cells through the EDG receptors.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF EDG5 IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF EDG5: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY EDG5: No information.
Database accession numbers
Revised June 25, 2008