|EDG6||EDG5( endothelial differentiation, lysophosphatidic acid G-protein coupled receptor, 6)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Burkitt lymphoma cell
|EDG6 is specially expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung, Burkitt lymphoma cell lines, in adult and fetal spleen and peripheral leukocytes. Expression is low in adult thymus, lymph node, bone marrow, appendix and in fetal kiver, thymus and lung.|
MOLECULAR FAMILY NAME: Belongs to the G-protein coupled receptor family.
|LIGANDS AND MOLECULES ASSOCIATED WITH EDG6: No information.|
|EDG receptors bind lysophospholipids or lysosphingolipids as ligands and are involved in cell signaling in many cell types. EDG6 is the receptor for lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits a diverse physiological effect on most types of cells and tissues. EDG6 may be involved in cell migration processes that are specific for lymphocytes. EDG6 is intronless and is specifically expressed in the lymphoid tissue.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF EDG6 IN INTACT ANIMAL: No information.
Database accession numbers
Revised June 25, 2008