EDG6 EDG5( endothelial differentiation, lysophosphatidic acid G-protein coupled receptor, 6)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Multi-pass
Leukocyte
Spleen
Hematopoietic Cell
Lymphoid Cell
Lung
Mouth
Burkitt lymphoma cell

Expression
EDG6 is specially expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung, Burkitt lymphoma cell lines, in adult and fetal spleen and peripheral leukocytes.  Expression is low in adult thymus, lymph node, bone marrow, appendix and in fetal kiver, thymus and lung.

Structure

MOLECULAR FAMILY NAME:  Belongs to the G-protein coupled receptor family.

EDG6 is a multi-pass glycoprotein.  It contains an extracellular domain, 7 transmembrane domains and a cytoplasmic domain.  EDG6 shares 46% identity with human EDG3, a 44% identity with EDG1, 39% identity with EDG4 and a 37% identity EDG2.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.



Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH EDG6: No information.

Function
EDG receptors bind lysophospholipids or lysosphingolipids as ligands and are involved in cell signaling in many cell types.  EDG6 is the receptor for lysosphingolipid sphingosine 1-phosphate (S1P).  S1P is a bioactive lysophospholipid that elicits a diverse physiological effect on most types of cells and tissues.   EDG6 may be involved in cell migration processes that are specific for lymphocytes.  EDG6 is intronless and is specifically expressed in the lymphoid tissue.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF EDG6 IN INTACT ANIMAL: No information.

Comments

MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF EDG6: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY EDG6: No infiormation.



Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 8698O95977
Antibodies

Revised June 25, 2008


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