EDG7 EDG7 (endothelial differentiation, lysophosphatidic acid G-protein coupled receptor, 7)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Multi-pass
Prostate
Pancreas
Testis
Heart
35 / 35

Expression
EDG7 is expressed in prostate, testes, pancreas and heart and at moderate levels in lung and ovary.  There is no detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intesttine, colon or peripheral blood leukocytes.

Structure
MOLECULAR FAMILY NAME: Belongs to the G-protein coupled receptor family.

EDG7 is a mult-pass  353 aa glycoprotein.  It contains an extracellular domain, a transmembrane domain and a cytoplasmic domain.  EDG7 shares a 54% and 49% amino acid identity with EDG2 and EDG4 and less than 40% identity with EDG1.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFIFCATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH EDG7: No information.

Function
EDG7 functions as a cellular receptor for lysophosphatidic acid (LPA) and mediates a diverse cellular activities and  lysophosphatidic acid-envoked calcium mobilzation.  This receptor couple is predominantly to G(q)/11 α proteins and families of heteromeric G proteins.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF EDG7 IN INTACT ANIMAL

EDG7 may play a role in the development of ovarian cancer

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF EDG7: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY EDG7: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene23566Q9UBY5
Antibodies

Revised June 25, 2008


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