|EDG8||EDG8 (endothelial differentiation, spingolipid G-protein coupled receptor, 8)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|EDG8 is widely expressed in the brain, in the corpus callosum which is predominantly white matter. Expression is detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low expression is detected in many tissue extracts. Isoform 1 is expressed in peripheral tissues, whereas isoform 2 is expressed in the brain, spleen and perpherial blood leukocytes.|
|MOLECULAR FAMILY NAME: Belongs to the G-protein coupled receptor family.|
EDG8 is a multi-pass glycoprotein. It contains an extracellular domain, a transmembrane domain and a cytoplasmic domain.
Alterantive splicing yields 2 different isoforms.
POST-TRANSLATIONAL MODIFICATION: No information.
LIGANDS AND MOLECULES ASSOCIATED WITH EDG8: No information.
|EDG8 is a receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. EDG8 is coupled to both G(i/0) α and G(12) subclass of heteromeric G-proteins. EDG8 may play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTIONAL OF EDG8 IN INTACT ANIMAL
Over expression of EDG8 in leukemic large granular lymphocytes (LGL). LGL is a lymphoproliferative disorder often associated with autoimmune disease.
Database accession numbers
Revised June 25, 2008