EDG8 EDG8 (endothelial differentiation, spingolipid G-protein coupled receptor, 8)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Multi-pass
Brain
Spleen
Peripheral blood
Leukocyte
Placenta
Lung
Aorta

Expression
EDG8 is widely expressed in the brain, in the corpus callosum which is predominantly white matter.  Expression is detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen.  Low expression is detected in many tissue extracts.  Isoform 1 is expressed in peripheral tissues, whereas isoform 2 is expressed in the brain, spleen and perpherial blood leukocytes.

Structure
MOLECULAR FAMILY NAME: Belongs to the G-protein coupled receptor family.

EDG8 is a multi-pass glycoprotein.  It contains an extracellular domain, a transmembrane domain and a cytoplasmic domain.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alterantive splicing yields 2 different isoforms.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands

LIGANDS AND MOLECULES ASSOCIATED WITH EDG8: No information.



Function
EDG8 is a receptor for the lysosphingolipid sphingosine 1-phosphate (S1P).  S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.  EDG8 is coupled to both G(i/0) α and G(12) subclass of heteromeric G-proteins.  EDG8 may play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTIONAL OF EDG8 IN INTACT ANIMAL

Over expression of EDG8 in leukemic large granular lymphocytes (LGL).  LGL is a lymphoproliferative disorder often associated with autoimmune disease.

Comments

MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCIPTION OF EDG8: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY EDG8: No information.



Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene53637Q9H228
Antibodies

Revised June 25, 2008


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