EMR1 EMR1 (egf-like module containing, mucin-like, hormone receptor-like 1)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Multi-pass
Peripheral blood
Mononuclear Cell

Expression

EMR1 is widely expressed and increased levels in peripheral blood mononuclear cells.



Structure
MOLECULAR FAMILY NAME: Belongs to the G-protein coupled receptor family.

EMR1 is a multi-pass 833 aa glycoprotein.  It contains an extracellular N-terminus domain, which contains 6 epidermal growth factor (EGF) domains and 1GPS domain, and 3 extramembranous loops on either side of the plasma membrane, 7 transmembrane domains and a cytoplasmic C-terminal domain.  Upon ligand binding, cytoplasmic portions of the activated receptor interacts with heterotrimeric G coupled proteins to induces various second messengers.  One family that is composed exclusively of receptors to peptide hormones is recognized on the basis of homologous primary amino acid sequences.  The C-terminal of the protein contains the 7 hydrophobic segments and characteristic residues that allow the protein to be readily aligned with the various hormone receptors in the family.  At the N-terminus the 6 EGF-like modules are separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties.  Because of these unique charactristics, EMR1 is designated a putative EGF module-containing, mucin-like hormone receptor.

MOLECULAR MASS

POST-TRANSCRIPTIONAL  MODIFICATION

Alternative splicing yields 2 different isoforms.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH EMR1: No information.

Function
EMR1 may be involved in cell-cell interactions.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF EMR1 IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF EMR1: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY EMR1: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 2015Q14246
Antibodies

Revised June 25, 2008


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