|EMR1||EMR1 (egf-like module containing, mucin-like, hormone receptor-like 1)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
EMR1 is widely expressed and increased levels in peripheral blood mononuclear cells.
|MOLECULAR FAMILY NAME: Belongs to the G-protein coupled receptor family.|
EMR1 is a multi-pass 833 aa glycoprotein. It contains an extracellular N-terminus domain, which contains 6 epidermal growth factor (EGF) domains and 1GPS domain, and 3 extramembranous loops on either side of the plasma membrane, 7 transmembrane domains and a cytoplasmic C-terminal domain. Upon ligand binding, cytoplasmic portions of the activated receptor interacts with heterotrimeric G coupled proteins to induces various second messengers. One family that is composed exclusively of receptors to peptide hormones is recognized on the basis of homologous primary amino acid sequences. The C-terminal of the protein contains the 7 hydrophobic segments and characteristic residues that allow the protein to be readily aligned with the various hormone receptors in the family. At the N-terminus the 6 EGF-like modules are separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Because of these unique charactristics, EMR1 is designated a putative EGF module-containing, mucin-like hormone receptor.
Alternative splicing yields 2 different isoforms.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH EMR1: No information.|
|EMR1 may be involved in cell-cell interactions.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF EMR1 IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF EMR1: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY EMR1: No information.
Database accession numbers
Revised June 25, 2008