|EMR3 displays a predominantly leukocyte-restricted expression with highest levels in neutrophils, monocytes and macropages.|
MOLECULAR FAMILY NAME: Belongs to the G-protein coupled receptor family.
EMR3 is a multi-pass integral membrane 652 aa glycoprotein. It contains a N-terminal signal sequence, an extracellular domain which contains 2 EGF-like domains the first of which does not contain a calcium-binding sequence, a mucin-like spacer region with several N- and O-linked glycosyation sites, a putative GPCR proteolytic site, 7 transmembrane domains and a 51 aa cytoplasmic domain. The EGF-like domains are coupled to a TM7 domain via a mucin-like spacer domain. EMR3 is cleaved into 2 subunits, forming a heterodimer of a large extracellular domain (α subunit) non-covalently linked to a 7 transmembrane domain (β subunit). It has been shown that EMR3 and EMR2 share a high degree of sequence identity in the TM domains but not in the extracellular domains, whereas EMR2 and CD97 are highly homologous in the EGF-like domains but not in the transmembrane domains suggesting different ligand-binding and intracellular signaling activities.
Alternative splicing yields 3 different isoforms. Both a secreted protein and a soluble form is detected. A truncated EMR3 isoform contained only 2 EGF-like domains and no transmembrane and was predicted to be a soluble protein.
EMR3 has several N- and O-linked glycosylation sites. EMR3 is proteolytocally cleaved into 2 subunits, an extracellular α subunit and a 7-transmembrane subunit.
|LIGANDS AND MOLECULES ASSOCIATED WITH EMR3: No information.|
|EMR3 is a receptor which may plat a role in myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF EMR3 IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF EMR3: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY EMR3: No information.
Database accession numbers
June 25, 2008
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