|FCRL4||FCRL4 (Fc receptor-like 4), IRTA1 (immunoglobulin superfamily receptor translocation associated 1)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|FCRL4 is expressed in the perofollicular are of tonsil tissue, site rich in memory B cells. Low levels of expression were detected in spleen and lymph node but there is no expression in other tissues or lymphocyte cell lines tested.|
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family.|
FCRL4 is a 515 aa glycoprotein. It contains a signal sequence, an extracellular domain which contains 4 Ig-type domains and 3 potential N-linked glycosylation sites, a 16 aa transmembrane domain and an 106 aa cytoplasmic domain which contains 3 putative consensus SH2-binding domains having ITIMs and ITAMs.
Alternative splicing yields 7 different isoforms ( named IRTA1 and IRTA2)
FCRL4 has 3 potential N-linked glycosylation sites.
|LIGANDS AND MOLECULES ASSOCIATED WITH FCRL4: No information.|
|FCRL4 may be involved B cell malignancy.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF FCRL4 IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF FCRL4: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY FCRL4: No information.
Database accession numbers
Revised June 25, 2008