|GPA33||GPA33 (glycoprotein A33 [transmembrane])|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|43 / 43|
|GPA33 is expressed in normal gastrointestinal epithelium and in 95% of colon cancers.|
|MOLECULAR FAMILY NAME|
GPA33 is a single-pass type-1 319 aa glycoprotein. It contains a putative secretory signal sequence, a 213 aa extracellular domain which contains one Ig-like C2-type domain, one IG-like V-type domain and 3 potential glycosylation sites, a transmembrane domain and a 62 aa cytoplasmic domain. The sequence of the extracellular domain contains 2 domain characteristic of the CD2 subgroup of the Ig superfamily.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
GPA33 has 3 N-linked glycosylation sites and contains an approximately 8 kDa of N-linked carbohydrate.
|LIGANDS AND MOLECULES ASSOCIATED WITH GPA33: No information.|
|GPA33 may play a role in cell-cell recognition and signaling.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF GPA33 IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF GLA33: No information.
SUBSTRATES: No information.
EMZYMES WHICH MODIFY: No information.
Database accession numbers
Revised June 25, 2008