|HRH4||HRH4 (histamine receptor H4)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|HRH4 is expressed primarily in the bone marrow and eosinophils. It shows preferential distribution in cells in immunological relevance as T cell, dendritic cells, monocytes, peripheral blood leukocytes and neutrophils. Expression is in a wide variety of peripheral tissues including the heart, kidney, liver, lung, pancreas, skeletal muscle, thymus, prostate, small intestine, fetal liver and lymph node. Expression is either up-regulated or down-regulated upon activation of the lymphoid tissues and this regulation may depend on the presence of IL-10 or IL-13.|
|MOLECULAR FAMILY NAME: Belongs to the G-protein coupled receptor family.|
HRH4 is a multi-pass 390 aa glycoprotein. In contains an extracellular domain, a transmembrane domain which contains an asp residue in TM1, a DRY motif in TM2, a disulfide bond between the first and third extracellular loops, a trp in TM4 and TM6, a pro in TM5 and TM6 and a NPxxY motif in TM7 and a C-terminal cytoplasmic domain which contains a potential palmitoylation site. Various actions are mediated by histamine receptors H1, H2, H3 and H4. HRH4 (histamine receptor H4) belongs to the family 1 of G-protein coupled receptors and has the highest homology to histamine recepotor H3 among known G-protein coupled receptors. HRH4 amino acid is almost 40% identical to HRH3.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH HRH4: No information.|
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells and neurons. The H4 subclass of histamine receptors could mediate the histamine signals in perpheral tissues. HRH4 displays a significant level of constitutive activity and spontaneous activity in the absence of agonist.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF HRH4: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY HRH4: No information.
Database accession numbers
Revised June 25, 2008