|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|50 / 50|
|HPSE is highly expressed in placenta, spleen and weak expression is in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues.|
|MOLECULAR FAMILY NAME: Belongs to the glycosyl hydrolase 79 family.|
HPSE is a 543 aa heparanase glycoprotein. It contains an extracellular domain which contains 6 potential N-linked glycosylation sites, a hydrophic transmembrane domain and a cytoplasmic domain.
The cleavage of the 65 kDa isoform leads to the generation of a linker peptide, 8 kDa and 50 kDa product. The active isoform 8/50 kDa heterodimer, is resistant to degradation. Complete removal of the linker peptide appears to be a prerequisite to the complete activation of the enzyme.
HPSE has 6 N-linked glycosylated. HPSE is proteolytically processed. Glycosylation of the 50 kDa subunit appears to be essential for its solubility.
|LIGANDS AND MOLECULES ASSOCIATED WITH HPSE: No information.|
|Endoglycosidase is a cell surface and extracellular matrix-degrading enzyme. HPSE cleaves heparan sulfate proteoglycan (HSPGs) into heparan sulfate sides chains and core proleoglycans. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF HPSE IN INTACT ANIMAL
Due to HSPE contribution and angiogenesis, it is considered to be a potential target for anti-cancer therapies. The degration of heparan sulfate by heparanase is a key step in the extravasation of tumor cells and migrating leukocytes but is also important in physiologic processes including angiogenesis, would healing and smooth muscle proliferation.
Database accession numbers
Revised June 25, 2008