IL11RA IL11Rα (interleukin 11 receptor, α)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Prostate
Epithelial Cell
Neutrophil
Leukemia cell

Expression
IL11Rα is expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, an osteosarcoma cell lines, MG-63 and Saos-2.  Also expressed in normal and malignant prostate epithelial cell lines.

Structure
MOLECULAR FAMILY NAME: Belongs to the type-1 cytokine receptor family.

IL11Rα is a single-pass type-1 422 aa glycosylation.  It contains a signal sequence, an extracellular domain which contains a 2-domain homologous to those of the receptors IL-6R and ciliary neurotrophic factor (CNTFR), 2 fibronectin type-3 domains, a cytokine receptor-like domain and 1 Ig-like C2-type domain, a transmembrane domain and cytoplasmic domain.  IL-11 is a stromal cell derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use thr gp130 transducing subunit in their high affinity receptors.  IL11Rα encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family.  This particular receptor is very similiar to ciliary neurotrophic factor because of the type of domains in the extracellular domain.
 
MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.  There is a membrane isoform and a soluble isoform which lacks the entire cytoplasmic domain.

POST-TRANSLATIONAL MODIFICATION: No information.



Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH IL11EA: No information.

Function
IL11Rα is the receptor for IL-11.  The receptor systems for IL-6, LIF. OSM, CNTF, IL11 and CT1 can utilize IL-6ST for initiating signal transmission.  The IL11/IL11Rα/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF IL11Rα IN INTACT ANIMAL

Increased levels of IL11R are found in prostate carcinoma.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF IL11Rα: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY IL11Rα: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 3590Q14626
Antibodies

Revised June 25, 2008


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