|KLRG1||KLRG1 (killer cell lectin-like receptor subfamily G, member 1)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 2 glycoprotein
|KLRG1 is expressed in spleen, lymph node and periperal blood leukocytes. Expression is also in peripheral blood NK cells, B cells, T cells, a monocytic cell line and a basophilic leukemia cell line.|
|MOLECULAR FAMILY NAME: Belongs to the killer cell lectin-like receptor family.|
KLRG1 is a single-pass type-2 glycoprotein. It contains an extracellular domain which contains a Ig-like C-type lectin carbohydrate recognition domain and 4 potential N-linked glycosylation sites, a transmembrane domain and a cytoplasmic domain which has a ITIM-like motif.
Alternative splicing yeilds several isoforms but their full-length natures have not yet been determined.
KLRG1 has 4 potential N-linked glycosylation sites.
|LIGANDS AND MOLECULES ASSOCIATED WITH KLRG1: No information.|
|NK cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humor and cell-mediated immunity. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Inhibitory lectin-like receptors expressed on the surface of hematopoietic cells regulate immunocyte effector functions through interactions with specific ligands. MHC class I molecules are recognized by NK cells and all of these receptors contain a ITIM motif. Upon MHC engagement and tyrosine phosphorylation of the ITIM, SHP1 are recruited to the ITIM and an inhibitory signal cascade leads to the abrogation of NK cell activation.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF KLRG1 IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF KLRG1: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY KLRG1: No information.
Database accession numbers
Revised June 25, 2008