KLRG1 KLRG1 (killer cell lectin-like receptor subfamily G, member 1)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 2 glycoprotein
Peripheral blood
Spleen
Leukocyte
Lymph Node
NK Cell
T Cell
B Cell
Leukemia cell

Expression
KLRG1 is expressed in spleen, lymph node and periperal blood leukocytes.  Expression is also in peripheral blood NK cells, B cells, T cells, a monocytic cell line and a basophilic leukemia cell line.

Structure
MOLECULAR FAMILY NAME: Belongs to the killer cell lectin-like receptor family.

KLRG1 is a single-pass type-2 glycoprotein.  It contains an extracellular domain which contains a Ig-like C-type lectin carbohydrate recognition domain and 4 potential N-linked glycosylation sites, a transmembrane domain and a cytoplasmic domain which has a ITIM-like motif.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yeilds several isoforms but their full-length natures have not yet been determined.

POST-TRANSLATIONAL MODIFICATION

KLRG1 has 4 potential N-linked glycosylation sites.



Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH KLRG1: No information.

Function
NK cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation.  They can also regulate specific humor and cell-mediated immunity.  Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules.  Inhibitory lectin-like receptors expressed on the surface of hematopoietic cells regulate immunocyte effector functions through interactions with specific ligands.  MHC class I molecules are recognized by NK cells and all of these receptors contain a ITIM motif.  Upon MHC engagement and tyrosine phosphorylation of the ITIM, SHP1 are recruited to the ITIM and an inhibitory signal cascade leads to the abrogation of NK cell activation.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF KLRG1 IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF KLRG1: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY KLRG1: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene10219Q96E93
Antibodies

Revised June 25, 2008


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