Layilin LAYN (layilin)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Brain
Heart
Kidney
Liver
Lung
Lymph Node
Mammary gland
Oviduct
Ovary
Sperm
Thyroid

Expression
LAYN is expressed in brain, heart, kidney, liver, lung, lymph node, mammary gland, ovary, oviduct, spleen and thyroid gland.

Structure
MOLECULAR FMAILY NAME: Belongs to the layinin family.

LAYN is a single-pass type-1 glycoprotein.  It contains an extracellular domain which contains a C-type lectin domain, a transmembrane domain and a cytoplasmic domain.  LAYN is a transmembrane protein with homology to C-type lectins and is a membrane-binding site for talin in peripheral ruffles of spreading cells.  LAYN colocalizes with talin in membrane ruffles and is recruited to membrane ruffles in cells induced to migrate in in vitro wounding experiments and in perpherial ruffles in spreading cells.  A 10 aa motif in the layilin cytoplasmic domain is sufficient for talin binding.  A short region within talin's amino terminal was identified that was capable of binding layilin in vitro.  This region overlaps a binding site for focal adhesion kinase.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH LAYN: No information.

Function
LAYN is a receptor for hyaluronate.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF LAYN IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF LAYN: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY LAYN: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrez143903Q6UX15
Antibodies

Revised June 25, 2008


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