|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|LAYN is expressed in brain, heart, kidney, liver, lung, lymph node, mammary gland, ovary, oviduct, spleen and thyroid gland.|
|MOLECULAR FMAILY NAME: Belongs to the layinin family.|
LAYN is a single-pass type-1 glycoprotein. It contains an extracellular domain which contains a C-type lectin domain, a transmembrane domain and a cytoplasmic domain. LAYN is a transmembrane protein with homology to C-type lectins and is a membrane-binding site for talin in peripheral ruffles of spreading cells. LAYN colocalizes with talin in membrane ruffles and is recruited to membrane ruffles in cells induced to migrate in in vitro wounding experiments and in perpherial ruffles in spreading cells. A 10 aa motif in the layilin cytoplasmic domain is sufficient for talin binding. A short region within talin's amino terminal was identified that was capable of binding layilin in vitro. This region overlaps a binding site for focal adhesion kinase.
Alternative splicing yields 2 different isoforms.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH LAYN: No information.|
|LAYN is a receptor for hyaluronate.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF LAYN IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF LAYN: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY LAYN: No information.
Database accession numbers
Revised June 25, 2008