LGALS1 LGALS1 (lectin, galactoside-binding, soluble, 1 [galectin 1])
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Carbohydrate
Skeletal muscle
Thymus
Kidney
Placenta
Neuron
Hematopoietic Cell

Expression
LGALS1 is expressed on cardiac, smooth and skeletal muscle, neurons, thymus, kidney, placenta and hematopoietic cells.

Structure
MOLECULAR FAMILY NAME: Belongs to the galectin lectin family.

LGALS1 is a glycoprotein.  It contains a galectin domain and bind LGALS3.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGAND AND MOLECULES ASSOCIATED WITH LGALS1: No information.

Function
Galectins are a family of β-galactoside-binding proteins implicated in modulating cell-cell matrix interactions.  LGALS1 may act as an autocrine negative growth factor that regulates cell proliferation.  LGALS1 may regulate cell apoptosis and cell differentiation.  It binds β-galactoside, CD45, CD3 and CD4 but inhibits CD45 protein phosphatase.  :GALS1 is a homodimer.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF LGALS1 IN INTACT ANIMAL

Studies showed that LGALS1 is highly expressed in HIV-1 reservoir organs and is secreted by activated CD8 and it is proposed that it may be a significant factor that augments the efficiency of the HIV-1 infection process.

Comments

MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION IN LGALS1: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY LGALS1: No information.



Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 3956P09382
Antibodies

Revised June 25, 2008


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