|LGALS1||LGALS1 (lectin, galactoside-binding, soluble, 1 [galectin 1])|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|LGALS1 is expressed on cardiac, smooth and skeletal muscle, neurons, thymus, kidney, placenta and hematopoietic cells.|
|MOLECULAR FAMILY NAME: Belongs to the galectin lectin family.|
LGALS1 is a glycoprotein. It contains a galectin domain and bind LGALS3.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGAND AND MOLECULES ASSOCIATED WITH LGALS1: No information.|
|Galectins are a family of β-galactoside-binding proteins implicated in modulating cell-cell matrix interactions. LGALS1 may act as an autocrine negative growth factor that regulates cell proliferation. LGALS1 may regulate cell apoptosis and cell differentiation. It binds β-galactoside, CD45, CD3 and CD4 but inhibits CD45 protein phosphatase. :GALS1 is a homodimer.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF LGALS1 IN INTACT ANIMAL
Studies showed that LGALS1 is highly expressed in HIV-1 reservoir organs and is secreted by activated CD8 and it is proposed that it may be a significant factor that augments the efficiency of the HIV-1 infection process.
Database accession numbers
Revised June 25, 2008