LGALS4 LGALS4 (lectin, galactoside-binding soluble 4 [galection 4])
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Carbohydrate
Rectum
Small intestine
Colon

Expression

LGALS4 is expressed in the small intestine, colon and rectum.



Structure
MOLECULAR FAMILY NAME: Belongs to the galectin lectin family.

LGALS4 is a 323 aa glycoprotein.  It contains 2 homologous, approximately 150 aa carbohydrate recognition galectin domains and all amino acids are typically conserved in galectins.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH LGALS4: No information.

Function
Galectins are a family of β-galactoside binding proteins implicated in modulating cell-cell and cell-matrix interactions and they bind lactose and a related range of sugars.  LGALS4 may be involved in the assemby of adherens junctions.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF LGALS4 IN INTACT ANIMAL

LGALS4 is a S-type lectin that is strongly underexpressed in colorectal cancer.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF LGALS4: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY LGALS4: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 3960P56470
Antibodies

Revised June 25, 2008


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