LGALS7 LGALS7 (lectin, galactoside-binding soluble 7 [galectin])
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Carbohydrate
Epithelium
Keratinocyte

Expression
LGALS7 is expressed mainly in stratified squamous epithelium.  Expression is at all stages of epidermal differentiation such as in basal and suprabasal layers.  It is moderately repressed by retinoic acid.  Differential and in situ hybrizations indicated that LGALS7 is specifically expressed in keratinocytes.  The antigen localized to basal keratinocytes, although it was found, abeit at lower levels, in the suprabasal layers where it concentrated to areas of cell-to-cell contract. 

Structure
MOLECULAR FAMILY NAME: Belongs to the galectin lectin family.

LGALS7 is a glycoprotein.  It contains one galactin domain.  It is a monomer, cytoplasmic and nuclear and may be secreted by a non-classical secretory pathway.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH LGALS7: No information.

Function
Galectins belong to a family of related β-galactoside-binding lectins which are implicated in a variety of functions such as growth regulation, cell adhesion, migration, neoplastic transformation and immune responses.  The cellular localization and its striking down-regulation in cultured keratinocytes imply a role in cell-cell and/or cell-matrix interactions necessary for normal growth control.  It is a pro-apoptotic protein that functions intracellulary upstream of JNK activation and cytochrome release.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF LGALS7

LGALS7 was found to be upregulated in reepithelialization of corneal wounds and the stimulatory effect of LGALS7 was specifically inhibited by β-lactose but was uneffected by sucrose.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF LGALS7: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY LGALS7: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 3963P47929
Antibodies

Revised June 25, 2008


Contact us: Webmaster |  509-335-9515 | Accessibility | Copyright | Policies
College of Veterinary Medicine Washington State University, Pullman, WA, 99164-7010 USA
Copyright 1995-2003 Washington State University