LGALS8 LGALS8 (lectin, galactoside binding, soluble 8 [galectin 8])
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Carbohydrate

Expression
LGALS8 is expressed ubiquitous, is widely expressed in tumoral tissues and is selective by prostate carcinomas versus normal protstate and benign prostatic hypertrophy.

Structure
MOLECULAR FAMILY NAME: Belongs to the galectin lectin family.

LGALS8 is a 317 aa glycoprotein.  It contains 2 homologous but distinct carbohydrate-binding recognition galectin domains.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 3 different isoforms.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOELCULES ASSOCIATED WITH LGALS8: No information.

Function
Galectins are β-galactoside binding animal lectins which may be involved in the activation of various cell types through cross-linkage of cell surface glycoproteins.   They have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis and RNA splicing.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF LGALS8 IN INTACT ANIMAL

LGALS8 may be involved in some types of cancer and in cell cycle regulation.  Expression in tumoral tissues seems to be invoved in integrin-like cell interactions.  RT-PCR analysis detected expression of LGALS8 in several prostate cancers but only one benign prostatic hypertrophy sample was tested. 

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF LGALS8: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY LGALS8: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 3964O00214
Antibodies

Revised June 25, 2008


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