|LGALS9||LGALS9 (lectin, galactoside-binding soluble 9 [galectin 9])|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Lineage Restricted Molecule|
|LGALS9 is expressed in peripheral blood leukocytes and lymphatic tissues. Overexpression is found in Hodgkin's disease tissue. |
|MOLECULAR FAMILY NAME: Belongs to the galectin lectin family.|
LGALS9 is a 323 glycoprotein. It contains two homologous but distinct carbohydrate-binding recognition galectin domains. It contains a N- and C-terminal carbohydrate-binding domains connected by a link peptide.
Alternative splicing yields 2 different isoforms, one short and one long.
|LIGANDS AND MOLECULES ASSOCIATION WITH LGALS9: No information.|
|The galectins are a family of β-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS9 is a S-type lectin and binds galactosides. It may play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. The short isoform acts as an eosinophil chemoattractant. It is a ligand for HAVCR2/TIM3 and it induces Th1 lymphocyte death.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF LGALS9 IN INTACT ANIMAL
LGALS9 is strongly overexpressed in Hodgkin's disease tissue and it might participate in the interaction between H and RS cells with their surrounding cells and might play a role in the pathogenesis of this disease and/or its consistently associated immunodeficiency.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF LGALS9: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY LGALS9: No information
Database accession numbers
Revised June 25, 2008