LGALS9 LGALS9 (lectin, galactoside-binding soluble 9 [galectin 9])
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Lineage Restricted Molecule
Carbohydrate
Leukocyte
Peripheral blood
Hodgkins disease
Lymphatic tissue

Expression
LGALS9 is expressed in peripheral blood leukocytes and lymphatic tissues.  Overexpression is found in Hodgkin's disease tissue. 

Structure
MOLECULAR FAMILY NAME: Belongs to the galectin lectin family.

LGALS9 is a 323 glycoprotein.  It contains two homologous but distinct carbohydrate-binding recognition galectin domains.  It contains a N- and C-terminal carbohydrate-binding domains connected by a link peptide.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms, one short and one long.

POST-TRANSLATIONAL MODIFICATION

Ligands
LIGANDS AND MOLECULES ASSOCIATION WITH LGALS9: No information.

Function
The galectins are a family of β-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions.  LGALS9 is a S-type lectin and binds galactosides.  It may play a role in thymocyte-epithelial interactions relevant to the biology of the thymus.  The short isoform acts as an eosinophil chemoattractant.  It is a ligand for HAVCR2/TIM3 and it induces Th1 lymphocyte death.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF LGALS9 IN INTACT ANIMAL

LGALS9 is strongly overexpressed in Hodgkin's disease tissue and it might participate in the interaction between H and RS cells with their surrounding cells and might play a role in the pathogenesis of this disease and/or its consistently associated immunodeficiency.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF LGALS9: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY LGALS9: No information

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 3965O00182
Antibodies

Revised June 25, 2008


Contact us: Webmaster |  509-335-9515 | Accessibility | Copyright | Policies
College of Veterinary Medicine Washington State University, Pullman, WA, 99164-7010 USA
Copyright 1995-2003 Washington State University