LGALS12 LGALS12 (lectin, galactoside-binding soluble 12 [galectin])
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Carbohydrate
Adipose tissue
Leukocyte
Peripheral blood
Heart
Pancreas
Spleen
Thymus
Hemopoietic cell

Expression
LGLAS12 is not widely expressed but is predominant in adipose tissue.  RT-PCR detected expression in heart, pancreas, spleen, thymus and peripheral blood leukocytes with lower levels of expression in lung, skeletal muscle, kidney, prostate, testis, ovary and colon.  There is no expression in brain, placenta and liver.  Expression was also detected in hemopoietic and immune cell lines but not in other cell lines.

Structure
MOLECULAR FAMILY NAME: Belongs to the galectin lectin family.

LGALS12 is a 314 aa glycoprotein.  It contains two homologous but distinct carbohydrate-binding galectin domains. but it lacks a signal sequence and transmembrane domain.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 6 different isoforms.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH LGALS12: No information.

Function
LGALS12 binds lactose and may partcipate in the apoptosis of adipocytes.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF LGALS12 IN INTACT ANIMAL

Galectins may be involved with activation of various cell types through cross linkage of cell surfaces glycoproteins and may be involved in some types of cancer and in cell cycle regulation.  Transfection of cells with LGALS12 results in cell cycle arrest and abrogation in cancer cell lines so it may be a candidate tumor suppressor gene.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNS ELEMENTS WHICH REGULATE TRANSCRIPTION OF LGALS12: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY LGALS12: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene85329Q96DY0
Antibodies

Revised June 25, 2008


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