|LY96||LY96 (lymphocyte antigen 96), MD-2|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|MOLECULAR FAMILY NAME: Belongs to the lipopolysaccharide receptor family.|
LY96 is 160 aa secreted glycoprotein. It contains a 16 aa signal sequence and an extracellular domain which contains 2 N-linked glycosylation sites. LY96 is a heterogeneous homopolymer formed from homodimers and is disulfide linked. It belongs to the LPS recepeptor, a multi-protein complex containing CD14, MD-2 and TLR4. Ly96 binds to extracellular domains of TLR2 and TLR4.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
LY96 is N-glycosylated.
LIGANDS AND MOLECULES ASSOCIATED WITH LY96: No information.
|The LY96 (MD-2) protein appears to associate with Toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. It cooperates with TLR4 in the innate immunity tyo bacterial LPS and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. It enhances TLR4-dependent activation of NF-κB. Cells expressing both LY96 and TLR4 but not TLR4 alone, respond to LPS.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF LY96 IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF LY96: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY LY96: No information.
Database accession numbers
Revised June 25, 2008