LY96 LY96 (lymphocyte antigen 96), MD-2
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Unknown

Expression


Structure
MOLECULAR FAMILY NAME: Belongs to the lipopolysaccharide receptor family.

LY96 is 160 aa secreted glycoprotein.  It contains a 16 aa signal sequence and an extracellular domain which contains 2 N-linked glycosylation sites.  LY96 is a heterogeneous homopolymer formed from homodimers and is disulfide linked.  It belongs to the LPS recepeptor, a multi-protein complex containing CD14, MD-2 and TLR4.  Ly96 binds to extracellular domains of TLR2 and TLR4. 

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION

LY96 is N-glycosylated.

Ligands

LIGANDS AND MOLECULES ASSOCIATED WITH LY96: No information.



Function
The LY96 (MD-2) protein appears to associate with Toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling.  It cooperates with TLR4 in the innate immunity tyo bacterial LPS and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria.  It enhances TLR4-dependent activation of NF-κB.  Cells expressing both LY96 and TLR4 but not TLR4 alone, respond to LPS.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF LY96 IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF LY96: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY LY96: No information.



Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene17156Q9Y6Y9
Antibodies

Revised June 25, 2008


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