M160 CD163B, CD163L1 (CD163 molecule-like 1)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Spleen
Thymus
Liver
Monocyte
Macrophage
Lymph Node

Expression
M160 is expressed in two isoforms.  Isoform 1 is highly expressed in the spleen, lymph nodes, thymus and fetal liver but is weakly expressed in bone marrow and no epxression in peripheral blood leukocytes.  Expression is also restricted to monocyte and macrophage cell lines.  Isoform 2 is only expressed in spleen.

Structure
MOLECULAR FAMILY NAME: Belongs to the scavenger receptor cysteine rich family.

M160 is a single-pass type-1 glycoprotein.  M160-α has 1453 aa and is homologous to CD163.  It contains an extracellular domain which contains 12 scavenger receptor cysteine rich (SRCR) domains, 17 potential N-linked glycosylation sites, a transmembrane domain and a 71 aa cytoplasmic domain  with 3 potential phosphorylation sites. M160-β has a cytoplasmic domain of only 39 aa and lacks phosphorylation sites.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 3 different isoforms.  Isoform 1 (M160-α) and isoform 2 (M160-β) are cell membranes and isoform 3 is secreted.

POST-TRANSLATIONAL MODIFICATION

M160 has 17 potential linked glycosylation sites.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH M160: No information.

Function
M160 is a member of the SRCR superfamily.  Members of this family are secreted of membrane anchored proteins mainly found in cells associated with the immune system.  The family may mediate protein-protein interaction and ligand binding.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF M160 IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF M160: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY M160: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrez283316Q9NR16
Antibodies

Revised June 25, 2008


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