|M160||CD163B, CD163L1 (CD163 molecule-like 1)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|M160 is expressed in two isoforms. Isoform 1 is highly expressed in the spleen, lymph nodes, thymus and fetal liver but is weakly expressed in bone marrow and no epxression in peripheral blood leukocytes. Expression is also restricted to monocyte and macrophage cell lines. Isoform 2 is only expressed in spleen.|
|MOLECULAR FAMILY NAME: Belongs to the scavenger receptor cysteine rich family.|
M160 is a single-pass type-1 glycoprotein. M160-α has 1453 aa and is homologous to CD163. It contains an extracellular domain which contains 12 scavenger receptor cysteine rich (SRCR) domains, 17 potential N-linked glycosylation sites, a transmembrane domain and a 71 aa cytoplasmic domain with 3 potential phosphorylation sites. M160-β has a cytoplasmic domain of only 39 aa and lacks phosphorylation sites.
Alternative splicing yields 3 different isoforms. Isoform 1 (M160-α) and isoform 2 (M160-β) are cell membranes and isoform 3 is secreted.
M160 has 17 potential linked glycosylation sites.
|LIGANDS AND MOLECULES ASSOCIATED WITH M160: No information.|
|M160 is a member of the SRCR superfamily. Members of this family are secreted of membrane anchored proteins mainly found in cells associated with the immune system. The family may mediate protein-protein interaction and ligand binding.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF M160 IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF M160: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY M160: No information.
Database accession numbers
Revised June 25, 2008