|MS4A3||MS4A3 (membrane-spanning 4-domains, subfamily A, membrane 3, CD20L, HTM4 (hematopoietic cell 4-transmembrane protein.|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 3 glycoprotein, 4 span
|MS4A3 is expressed in hematopoietic cells and tissues and nonlymphoid tissues.|
Northern blot and reverse transcriptase-PCR analyses suggest that HTm4 mRNA expression is restricted to cells of hematopoietic origin.
MOLECULAR FAMILY NAME: Belongs to the membrane spanning 4A family.
|LIGANDS AND MOLECULES ASSOCIATED WITH MS4A3: No information.|
Members of the membrane-spanning 4A family are characterized by common structural features and similar intron/exon boundaries display unique expression patterns among hematopoietic cells and nonlymphoid tissues. MS4A3 likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. MS4A3 is a hematopoietic modulator for the G1-S cell cycle transition. It modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP). The C-terminal cytoplasmic domain is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF MS4A3: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY MS4A3: No information.
Database accession numbers
Revised June 25, 2008