MS4A4A MS4A4A (membrane spanning 4-domains subfamily A, member 4), CD20L1
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Multi-pass
Hemopoietic cell
Nonlymphoid tissue

Expression
MS4A4A is expressed on multiple hemopoietic cell lines and nonlymphoid tissues.

Structure
MOLECULAR FAMILY NAME: Belongs to the membrane spanning 4A family.

MS4A4A ia a multi pass 205 aa glycoprotein.  It contains a N-terminal extracellular domain, 4 highly conserved transmembrane domains and a C-terminal cytoplasmic domain which has a conserved phosphorylation site in the intracellular loop.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms but not all isoforms have been described.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH MS4A4A: No information.

Function
MS4A4A encodes the membrane spanning 4A family.  Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues.  MS4A4A may be involved in signal transduction as a component of a multimeric receptor complex.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF MS4A4A IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF MS4A4A: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY MS4A4A: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene51338Q96JQ5
Antibodies

Revised June 25, 2008


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