MAG (myelin associated glycoprotein), SIGLEC-4A
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|100 / 100|
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family.|
MAG is a single-pass type-1 glycoprotein. It contains an extracellular domain which contains 4 Ig-like C2-type domains and 1 Ig-like V-type domain, a transmembrane domain and a cytoplasmic domain. MAG belongs to the sialic acid binding Ig-like lectins family within the Ig gene superfamily.
Alternative splicing yields 2 different isoforms.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH MAG: No information.|
|MAG is an adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. It preferentially binds to α1,3-linked sialic acid. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE REVELANCE AND FUNCTION OF MAG IN INTACT ANIMAL: No information.
Database accession numbers
Revised June 25, 2008