MAG 

MAG (myelin associated glycoprotein), SIGLEC-4A

Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
100 / 100

Expression


Structure
MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family.

MAG is a single-pass type-1 glycoprotein.  It contains an extracellular domain which contains 4 Ig-like C2-type domains and 1 Ig-like V-type domain, a transmembrane domain and a cytoplasmic domain.  MAG belongs to the sialic acid binding Ig-like lectins family within the Ig gene superfamily.

MOLECULAR MASS

POST-TRASCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH MAG: No information.

Function
MAG is an adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells.  It preferentially binds to α1,3-linked sialic acid.  It is thought to be involved in the process of myelination.  It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE REVELANCE AND FUNCTION OF MAG IN INTACT ANIMAL: No information.

Comments

MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF MAG: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY MAG: No information.



Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 4099P20916
Antibodies

Revised June 25, 2008


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