|MPZL1||MPZL1 (myelin protein zero-like 1), PZR|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|43 / 43|
|MPZL1 is expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hemotopoietic tissues and fetal liver. Isoform 1 and 3 are expressed un CD14-peripheral blood monocytes and pre-B cell progentiors. Isoform appears to be the major isoform in CVD34 promyelocytic and promonocytic cells but during differentiation in monocytic cells, the expression level decreases and that of isoform 1 increases. Isoform 1 is prominant in stromal cells and to a lesser extent in umbelical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line.|
MOLECULAR FAMILY NAME: Belongs to the myelin protein zero family.
|LIGANDS AND MOLECULES ASSOCIATED WITH MPZL1: No information.|
|MPZL1 is a cell surface receptor which is involved in signal transduction processes. It recruits SHP-2 to the cell membrane and is a putative substrate. It is a major receptor to concanavalin (ConA) and is involved in cellular signaling induced by ConA which probably induces Src family tyrosine protein kinases. Isoform 3 seem to have a dominant negative role as it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1 but not isoform 2 and isoform 3 may be involved in regulation of integrin mediated cell motility. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF MPZL1 IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF MPZL1: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY MPZL1: No information.
Database accession numbers
Revised June 25, 2008